Moreover, only FLT-PET/CT was able to distinguish both between grade III and IV gliomas in IDH1-wildtype tumours and grade II and III gliomas in IDH1-mutant tumours FLT-PET/CT can improve glioma differentiation based on the 2016 WHO classification in newly diagnosed gliomas, but caution must be paid for tumours without contrast enhancement and further studies should be conducted with more cases. The gene discussed is IDH1; the disease is glioma.