The MCF7-hGH cells were reported to be significantly resistant to apoptosis, mediated by an autocrine GH-dependent p38-MAPK-induced CHOP[110], along with increased metastasis and anchorage abilities in collagen and 3D-matrices[109] due to autocrine-GH-directed HOXA1 mediated expression of cMyc, Cyclin-D1, and Bcl2 - genes involved in facilitating tumor invasion[128]. The gene discussed is GH1; the disease is neoplasm.