Autocrine/paracrine GH was further found to turn on EMT cascade in human colorectal cancer cells, where E-cadherin was suppressed with a concomitant increase in mesenchymal proteins Vimentin and FN1, via ERK1/2[131]; while exogenously added GH increased Snail and Twist2 and suppressed PTEN activity[96]. This evidence concerns the gene GH1 and colorectal cancer.