We observed that doxorubicin, cisplatin, paclitaxel, oridonin, and vemurafenib, in four different human melanoma cell lines, in presence of GH differentially upregulated ABCB1, ABCB5, ABCB8, ABCC1, ABCC2, ABCG1, and ABCG2 multi-drug efflux pump expressions. The gene discussed is ABCG2; the disease is melanoma.