Forced GH expression in stably transfected Huh7-hGH and HepG2-hGH cells induced a JAK2-STAT3 mediated suppression of the tight junction component CLAUDIN1, leading to conferral of CSC properties, including upregulated ABCG2, NANOG, SALL4, and other CSC markers and mediators in these liver cancer cells[170]. This evidence concerns the gene GH1 and liver cancer.