Additionally, the GH-deficient Ames’ mice (Prop1-/-) as well as the GHRKO mice had higher colonic p53 expression than WT counterparts while APC-deficient Ames’ mouse (APCmin+/- Prop1-/-) had lower incidence of colonic neoplasms than APCmin+/- counterparts[96] highlighting the GH-p53 association. This evidence concerns the gene TP53 and colonic neoplasm.