LEP and diabetes mellitus: Moreover, leptin is responsible for reducing bone fragility by inducing osteoblast proliferation and inhibiting osteoclastogenesis.55 Therefore, the skeletal fragility found in db/db mice is likely primarily caused by the loss of leptin's effects, which does not mechanistically mimic the proinflammatory state of diabetes that induces osteoclastogenesis and the subsequent skeletal fragility found in diabetic humans.56