miR-124, a brain-enriched miRNA emerging as an important regulator of gastrulation and neural development, has recently been confirmed as a tumor suppressor through targeting several crucial genes, such as Slug, LHX2, and CBL.5, 6, 7 As a potential tumor suppressor gene, miR-124 has been shown to regulate proliferation, migration, and invasion in certain cancers.8, 9, 10, 11 Pertinent to chemotherapy, Qiao et al.12 Here, LHX2 is linked to neoplasm.