In the present study, an eight-lncRNA signature (TSPEAR-AS1, LINC00511, LINC01136, MKLN1-AS, LINC00506, KRTAP5-AS1, ZNF252P-AS1, and THUMPD3-AS1) was identified as an independent prognostic biomarker for HBV-positive HCC patients. This evidence concerns the gene THUMPD3 and hepatocellular carcinoma.