These signature lncRNAs may be involved in HBV-HCC by coexpressing with mRNAs (LINC00511-CABYR, THUMPD3-AS1-TRIP13, LINC01136-SFN, LINC00506-ANLN, and KRTAP5-AS1/TSPEAR-AS1/MKLN1-AS/ZNF252P-AS1-MC1R) or functioning as a ceRNA (THUMPD3-AS1-hsa-miR-450a-TRIP13) to regulate the cell cycle-related biological processes or pathways. The gene discussed is TSPEAR; the disease is hepatocellular carcinoma.