Firstly, we evaluated the prognostic significance of AATF using the data of 2521 HCC patients from the GEO, TCGA, and ICGC databases (GSE22058, n = 197; GSE36376, n = 433; GSE14520, n = 445; GSE54236, n = 161; GSE63898, n = 396; GSE64041, n = 120; GSE76427, n = 167; TCGA, n = 370; and ICGC, n = 232). The gene discussed is AATF; the disease is hepatocellular carcinoma.