Our findings revealed that CYFIP2 (AUC = 0.949), HOXB5 (AUC = 0.908), PTPN3 (AUC = 0.952), MARCKSL1 (AUC = 0.962), PTCH1 (AUC = 0.981), and CDC20 (AUC = 0.956) could significantly distinguish BCC samples and healthy controls, implying that these genes might serve as diagnostic makers for BCC detection (Figure 5). This evidence concerns the gene HOXB5 and skin basal cell carcinoma.