A high dosage of MRS2578 exhibited upregulation of chemokines, local macrophage infiltration, activation of MMP-2/9, and subsequently ECM fragmentation, indicating that MRS2578 may exacerbate AAA and increase mortality at least in part by activating the VCAM-1/MCP-1-macrophages-MMP-2/9 inflammatory pathway. This evidence concerns the gene VCAM1 and triple-A syndrome.