Consistently, higher activities of MMP-2 and MMP-9 were detected in mice treated with both Ang II and MRS2578 through gelatin zymography, especially in the Ang II+MRS-32 mg group (Figure 2(e)), demonstrating that MRS2578 could contribute to rupture of AAA by accelerating disruption of the medial layer via increasing the expressions and activities of MMP-2 and MMP-9. This evidence concerns the gene MMP2 and triple-A syndrome.