In early peritoneal dissemination of ovarian cancer, the dormant tumor cells always interact with the relative static ECM components in vivo, which mainly consist of a nanofibrous mesh of structural proteins such as fibronectin, collagen, elastin, and laminin.[35, 132] These ECM components are key to support various cell signaling communications and cell phenotype transformation and maintain tumor cells survival in vivo and the malignant proliferation. The gene discussed is LAMB2; the disease is neoplasm.