FN1 and ovarian cancer: In early peritoneal dissemination of ovarian cancer, the dormant tumor cells always interact with the relative static ECM components in vivo, which mainly consist of a nanofibrous mesh of structural proteins such as fibronectin, collagen, elastin, and laminin.[35, 132] These ECM components are key to support various cell signaling communications and cell phenotype transformation and maintain tumor cells survival in vivo and the malignant proliferation.