To date, the role of the Wnt signaling pathway in cancer metabolism remains under‐investigated.[15] Wnt induces anaplerosis along with increased glucose consumption and lactate production.[14, 36] Here, we reported that PC‐deficient BCA cells also had lower canonical Wnt signaling, implicating the crosstalk between a key enzyme of anaplerosis and Wnt signaling. Here, BLNK is linked to cancer.