These foci become surrounded by tumor cells which eventually form pseudopalisade and upregulate the expression of VEGF, leading to vascular hyperplasia, including glomeruloid vascular proliferation.[108] In contrast to this sequence of vessel cooption, vessel regression and angiogenesis, real‐time data suggest a dynamic interplay of vessel cooption, and angiogenesis in tumor evolution. This evidence concerns the gene VEGFA and neoplasm.