MTOR and glioma: NLGN3 acts as a mitogen by recruiting PI3K‐mTOR oncogenic pathway to induce glioma cells proliferation.[41] In 2019, two studies showing the electrical and synaptic integration of glioma cells in neuronal circuits were published.[42, 43] Both studies demonstrated the existence of spontaneous, excitatory postsynaptic potentials in tumor cells mediated by α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptors, which could bring to the fore new therapeutic strategies for high‐grade gliomas.