Members of Rho‐family GTPases RhoA, Rac, and Cdc42 are known to regulate the assembly of the actin structures required for cell motility in glioma cells, which are stress fibers, lamellipodia, and filopodia.[95] Rho is mainly involved in the formation of stress fibers and focal adhesions, Rac activates the formation of lamellipodia and Cdc42 is involved in the formation of filopodia and is also known to activate Rac.[96] Rho GTPases promote myosin‐actin interactions through Rho‐associated coiled‐coil kinase (ROCK). This evidence concerns the gene CDC42 and central nervous system cancer.