uPA and its receptor (uPAR) have been shown to be overexpressed in GBM.[91] Binding of uPA and uPAR directs plasmin activity to the migrating tumor cell surface and results in increased tumor cell migration and invasion.[83] The PI3K/AKT signaling pathway is inhibited when uPA is downregulated, suggesting that this pathway regulates uPA‐induced cell migration.[92]. This evidence concerns the gene AKT1 and neoplasm.