NLGN3 and glioma: This network is able to communicate via connexin 43 (Cx43) gap junctions and could be used as a route for brain invasion, proliferation and interconnection over long distances.[40] In the same year, Venkatesh et al. showed that neuronal activity promotes high‐grade glioma proliferation and growth through neuroligin‐3 (NLGN3) secretion.