There were 46 overlapping targets of HF and Huangqi, including PXDH, NOS2, PLAT, SOD1, PON1, IFNG, PPARG, CRP, NOS3, SERPINE1, ADRB1, TNF, VEGFA, CCL2, and so on, accounting for 11.14% of the total number of HF targets. The gene discussed is IFNG; the disease is hydrops fetalis.