APLN and cancer: It was found that overlapping targets of HF and Huangqi were involved in 65 pathways by using ClueGO analysis, including AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, HIF-1 signaling pathway, apelin signaling pathway, VEGF signaling pathway, proteoglycans in cancer, TNF signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, and so on (Figure 7).