For example, in acute allergic contact dermatitis model, pretreatment of mouse ears with resveratrol reduced the density of CD3+ cells by≈90% in parallel with significant reduction of ear thickness and expression levels of intercellular adhesion molecule 1 (ICAM-1), C-X-C motif chemokine ligand 10 (CXCL10), C-C motif chemokine ligand 2 (CCL2), and IFN-κ in the epidermis [113], suggesting preventive benefits of topical resveratrol in acute allergic contact dermatitis. This evidence concerns the gene CCL2 and allergic contact dermatitis.