We previously reported that the lncRNA LINC01638 was highly expressed in the TN-BC subtype and LINC01638 activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation to maintain the epithelial–mesenchymal transition and cancer stem cell-like state of TN-BC cells12. This evidence concerns the gene SPOP and breast cancer.