To identify the possible consequences of the loss of QKI in pathological conditions, such as osteoporosis, and to further validate the influence of QKI deficiency on bone mass, we simulated the postmenopausal status of women through OVX, in which the body loses the protective effects of estrogen, bone homeostasis is destroyed, and bone mass is reduced, and then lead to osteoporosis40. The gene discussed is QKI; the disease is osteoporosis.