GPX4 and cancer: Ferroptosis is a recently recognized form of cell death and plays a crucial role in cancer treatment.17,18 GPX4 inactivity and subsequent ROS accumulation are central regulators of ferroptosis.19,20 Ferroptosis also contributes to the antitumor function of several tumor suppressors, such as p53 and BRCA1-associated protein 1 (BAP1).