MUC15 and renal cell carcinoma: Moreover, based on analyzing RNA-sequence in cohort of no-paired samples (315 cases RCC tissues and 72 cases normal kidney tissues) and 72 paired samples from the The Cancer Genome Atlas (TCGA), we could concluded that MUC15 mRNA expression level is obviously lower in RCC tissues (Fig. 1b, c, ***P < 0.001).