Huang et al.13 showed that mRNA and protein expression of MUC15 were significantly higher in colorectal tumors compared with their normal counterparts, furthermore, in vitro and in vivo experiments showed that overexpression of MUC15 could activate extracellular signal-regulated kinase 1/2 and promote the progression of human colon cancer cells. The gene discussed is MAPK3; the disease is colorectal neoplasm.