A prediction of the presence of IDH mutation in the sample might warrant a more extended surgical resection, aimed at a complete removal of the tumour, in order to improve patient’s prognosis, whilst the presence of an IDH-wildtype genotype would suggest a sub-total/partial but neurologically safer resection, leaving the post-operative management of the tumour remnant to the radiochemotherapy. The gene discussed is IDH1; the disease is neoplasm.