Given that expression data from patients revealed a BET protein signature, and dBRD4 targeting defects could be rescued by HDACi treatments, it is tempting to speculate that restoring acetylation levels in patients could possibly revert gene misexpression and consequently alleviate some of the symptoms associated with the Koolen-de Vries syndrome. The gene discussed is DNER; the disease is Koolen-de Vries syndrome.