KLK3 and Familial prostate cancer: Clinically insignificant prostate cancer (CiPCa) is defined as T1c or T2a, PSA < 10 ng/ml, PSAD < 0.15 ng/ml,< 3 positive cores with <50% cancer, GS 6 (GrG1); 3 + 4, if MR-targeted biopsy performed20.