TP53 and hepatocellular carcinoma: The study includes HCC cell lines in well- (HepG2, Hep3B, and Huh7), moderately (SNU423), and poorly (SNU449) differentiated stages, as well as expressing wild-type p53 (HepG2), non-sense p53 mutation (Hep3B), inframe p53 gene deletion (SNU423), and p53 point mutation (Huh7 and SNU449)14,15.