VHL and nonpapillary renal cell carcinoma: Qing Zhang et al.12 have found that Zinc fingers and homeoboxes 2 (ZHX2) is a novel VHL substrate transcription factor by using a genome-wide human cDNA library strategy; and they reported that depletion of ZHX2 could inhibit the proliferation of VHL-deficient ccRCC cell lines through impairing NF-κB pathway.