Apoptosis analysis showed that either EPAS1 or ZHX2 knockdown could induce cell apoptosis (Fig. 2c–f), and wound healing assay showed both can inhibit cell migration (Supplementary Fig. S1b, c), which means that ZHX2 may have similar function with HIF-2a in ccRCC proliferation. The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.