Here, we found that the m6A level of TRIM11 is higher in CNE1-DDP and CNE2-DDP cells than in CNE1 and CNE2 cells, and m6A modification of TRIM11 mRNA improves its RNA stability, which may at least partially account for the upregulation of TRIM11 in NPC drug-resistant cells. Here, TRIM11 is linked to nasopharyngeal carcinoma.