Numerous studies have suggested that upregulation of the ATP-binding cassette (ABC) family proteins promotes drug resistance in various cancers by mediating the efflux of cytotoxic chemotherapeutics28; ABCC9 belongs to the ABCC subfamily, which is best known for containing the majority of drug transporters and multidrug resistance proteins (MRPs)28. The gene discussed is ABCB6; the disease is cancer.