Moreover, immunohistochemical staining showed that tumor neovascularization index CD31 expression was significantly lower in LN229-K.D.-NKILA tumor tissue than in LN229-K.D.-NC tumor tissue, but significantly higher in the U87-O.E.-NKILA group than in the U87-O.E.-NC group. The gene discussed is PECAM1; the disease is neoplasm.