In contrast to the presence of infiltrating F4/80-positive macrophages and the elevated expression of F4/80 and Ly6c, the mRNA expression of TNFα, IL-6, Il-1β, and IL-17 were paradoxically downregulated in the tumor-bearing 12-month-old Atg7ΔHep livers (Supplementary Fig. S4). The gene discussed is TNF; the disease is neoplasm.