Indeed, real-time PCR analysis indicated that expression of Angpt2 and Pdgfb, but not Vegfa and Angpt1, were significantly upregulated in Atg7ΔHep tumor and non-tumor livers, compared with wild-type Atg7 F/F mice (Supplementary Fig. S3), suggesting the differential involvement of angiogenic factors in the peritumoral niche of Atg7ΔHep mice. This evidence concerns the gene ANGPT1 and neoplasm.