USP10 and non-small cell lung carcinoma: To verify the role of USP10 in regulating HDAC6 protein levels, we next depleted USP10 with specific shRNAs and observed a significant decrease of HDAC6 protein expression in four NSCLC cell lines: H157, H125, H1299, and H23, as well as two ovarian cell lines: SKOV3 and ES-2 (Fig. 2b).