LGR5 and neoplasm: Our findings suggest that a putative subpopulation of LGR5+ epithelial stem-like cells in AM (AM-EpiSCs) capable of generating tumor 3D organoids may contribute to pathogenesis of AM, and targeted inhibition of both BRAF and LGR5 potentially serves a novel nonsurgical adjuvant therapeutic approach for this aggressively benign jaw tumor.