CD8A and head and neck squamous cell carcinoma: In addition to high CD8+ T-cell infiltration, we also identified that very high immune scores, that is, high IFN-γ score, high CYT score, and high T-eff signature score (top 20% versus bottom 20% arbitrary cutoffs) were all survival-favoring features among HNSCC patients (Fig 5F–H; versus patients with tumors of respective low scores).