CD8A and head and neck squamous cell carcinoma: Subsequent immune landscape examination across all seven signaling pathways by Tumor Immune Estimation Resource (TIMER) analysis (Li et al, 2016, 2017) reveals for the first time that treatment-naïve MAPK pathway-mutated HNSCC tumors are the only tumors with significant elevation of CD8+ T-cell infiltration within the tumor microenvironment (Fig 4A and B; P = 0.0030; size of red-outlined bubbles indicating significance level).