Such a mutant-specific phenomenon was further supported by proteomic findings in MAPK-mutant HNSCC cell lines (N = 12, Cancer Cell Line Encyclopedia [CCLE] [Ghandi et al, 2019]) and in relatively homogeneous MAPK-mutant patient tumors with high allele frequencies (>40%), in which p-MAPK(T202/Y204) and p-ErbB3 levels were negatively correlated with high Spearman R correlation coefficients of −0.5874 (P = 0.0244) and 0.4333 (P = 0.1250, a trend in non-microdissected TCPA tumors; Fig 2D), respectively. The gene discussed is ERBB3; the disease is head and neck squamous cell carcinoma.