Whereas for JAK/STAT- and PI3K-mutated HNSCC, only CD8+ T-cells are increased with no obvious concurrent activation of full active CYT, T-eff, and IFN-γ signatures, suggestive of potentially weaker CD8+ T-cell cytolytic activity in situ (Fig 4A). The gene discussed is IFNG; the disease is head and neck squamous cell carcinoma.