Data from The Cancer Protein Atlas (TCPA, https://tcpaportal.org/tcpa/, (Li et al, 2013, 2017a)) have established tumoral overexpression of phospho-ErbB3(Y1289) as the top 1 protein-signaling event most significantly associated with decreased HNSCC patient survival among 273 key signaling proteins examined (P = 0.0006, Fig 2A and Table S4 shows top 20 signaling proteins of significant survival correlations). The gene discussed is ERBB3; the disease is head and neck squamous cell carcinoma.