Over the study period, there was no evidence that APOE*ε4+ was a risk factor for depression, including any depression (OR = 0.94 (95% CI 0.77; 1.16), P = 0.573), major depression (OR = 0.96 (0.60; 1.53), P = 0.860), minor depression (OR = 0.94 (0.67; 1.30), P = 0.695) or depressive symptomology (IRR = 1.02 (95% CI 0.97; 1.08), P = 0.451). This evidence concerns the gene APOE and major depressive disorder.