There was no consistent evidence of APOE*ε4 + 4-year risk for any depression (OR = 0.92 (95% CI 0.73–1.15), P = 0.433), major depression (OR = 0.73 (95% CI 0.41–1.30), P = 0.283), minor depression (OR = 0.95 (95% CI 0.62–1.45), P = 0.805) or depressive symptomology according to the GDS (IRR = 1.04 (95% CI 0.98–1.10), P = 0.099). The gene discussed is APOE; the disease is major depressive disorder.