There was no 12-year risk of APOE*ε4+ for any depression (OR = 1.08 (95% CI 0.85–1.36), P = 0.533), major depression (OR = 1.30 (95% CI 0.75–2.25), P = 0.344), minor depression (OR = 1.17 (95% CI 0.75–1.81), P = 0.485) or depressive symptomology according to the GDS (IRR = 1.02 (95% CI 0.96–1.08), P = 0.523). Here, APOE is linked to depressive disorder.