There was no 8-year risk of APOE*ε4+ for any depression (OR = 0.86 (95% CI 0.67–1.10), P = 0.221), major depression (OR = 0.96 (95% CI 0.56–1.65), P = 0.890), minor depression (OR = 0.74 (95% CI 0.46–1.19), P = 0.218) or depressive symptomology according to the GDS (IRR = 1.01 (95% CI 0.96–1.06), P = 0.808). Here, APOE is linked to major depressive disorder.