The therapeutic effects of TL1A blockade on clinical score and bone erosions in CIA combined with previous data on efficacy of TL1A blockade or TL1A/DR3 deficiency in animal models of asthma, multiple sclerosis, and inflammatory bowel disease suggest that TL1A blockade should be further explored as a therapeutic strategy in these diseases. Here, TNFSF15 is linked to multiple sclerosis.