The level of the phosphorylated form of TDP43 (Cosmobio, #TIP-PTD-P01), a pathological feature of ALS [17], was also significantly increased (~ 2 fold change) in hTDP43 mice infused with ALS-CSF as compared to control CSF (Fig. 1 i). Here, TARDBP is linked to amyotrophic lateral sclerosis.