To test the hypothesis that CSF constitutes a route of ALS dissemination including TDP43 pathology, we have performed chronic intracerebroventricular infusion of pooled CSF samples from sporadic ALS patients or from non-ALS control samples into transgenic mice expressing human TDP43WT which do not develop pathological phenotypes [46]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.