However, TAB1 overexpression (TAB1-OE) attenuated the inhibition effects of Sur-X on colorectal cancer cells and decreased the expression of p-MLKL, which further confirmed the disruption of XIAP-TAB1 interactions by Sur-X (Fig. 5h-i and Figure S4D-E). The gene discussed is MLKL; the disease is colorectal cancer.