We identified that siRNA-mediated knockdown of Msn augmented the release of TNF and IL-10 by primary mouse microglia in response to LPS stimulation TNF or tumor necrosis factor is a pro-inflammatory molecule [66, 67] while IL-10, although traditionally considered anti-inflammatory, has been found to have detrimental effects in AD models [68, 69]. This evidence concerns the gene TNF and Alzheimer disease.