Lastly, since Msn expression is observed in microglia proximate to Aβ plaques in human AD and 5xFAD mouse brains, we sought to determine Msn protein abundance in a published proteomic analysis of laser-micro-dissected Aβ plaques from the hippocampus and adjacent entorhinal cortex of rapidly progressive AD (rpAD) and sporadic AD (spAD) cases [17]. This evidence concerns the gene MSN and Alzheimer disease.