In this study, we examined the relationship between brucellosis and cytokine levels, and found IL-4, IL-6, IL-10, IL-17, IFN-γ, and TNF-α were all risk factors for brucellosis, although only IL-6 and INF-γ were independent risk factors for the severity of brucellosis. The gene discussed is IL4; the disease is brucellosis.