Flow cytometry analysis showed that SH3BGRL overexpression significantly compromised the cisplatin-induced cell apoptosis in MCF-7 cells, while SH3BGRL knockdown sufficiently enhanced cell apoptosis in MDA-MB-453 cells (Fig. 5a; Supplemental Figure S4, Cisplastin), indicating the dual effects of SH3BGRL in breast tumor cell proliferation and anti-cancer drug resistance. Here, SH3BGRL is linked to cancer.