ERBB2 and breast carcinoma: Now, breast cancers are classified into four major types as luminal A (ER+and/or PR+, HER2−, Ki-67+ < 20%), luminal B (ER+ and/or PR+, HER2−, Ki-67+ ≥ 20%), luminal B-HER2+ (ER+ and/or PR+, HER2+), HER2+ (ER−PR−HER2+), and triple-negative (TN; ER−PR−HER2−), based on the molecular profile [2].