Results indicated that endogenous SH3BGRL knockdown in MDA-MB-453 cells sensitized cell sensitivity to Lapatinib, while SH3BGRL overexpression in MCF-7 cells significantly enhanced cell resistance to Lapatinib (Fig. 5c), indicating that SH3BGRL enhances the HER2-positive breast cancer cells resistance to Cisplatin and the HER2-targeted therapies. This evidence concerns the gene ERBB2 and breast carcinoma.