Omipalisib (GSK2126458), a potent inhibitor of mTOR and phosphatidylinositol 3-kinase (PI3K) [24], has been tested in a randomised, placebo-controlled study of IPF, which found that omipalisib has an acceptable tolerability and that target engagement was confirmed (NCT01725139) [25]. The gene discussed is MTOR; the disease is idiopathic pulmonary fibrosis.