After controlling for age, race, PSA and Gleason sum, PC-CIN-high is significantly associated with higher odds of M1 stage, CRPC, PC-death and all-cause mortality in multivariate analysis (OR 10.84, 16.13, 6.26 and 6.00, respectively; all p < 0.001, Table 1). This evidence concerns the gene KLK3 and pachyonychia congenita.