BCR and pachyonychia congenita: Comparison of diagnostic biopsies (PNBX) from patients with de novo metastatic (M1) CSPC and published mCRPC datasets revealed a common gene set with CIN70 genes, that could be simplified into a 7-gene classifier (PC-CIN) capable of predicting metastatic stage, poor outcomes (BCR, CRPC progression, metastasis), and lethality (PC-specific and all cause mortality) in PC cohorts.