The volume of primary lung cancer and the number of metastatic nodules both decreased in an orderly fashion for the following four groups: the NC group, the AZD4547 group, the sh-CCND1 group and the sh-CCND1 plus AZD4547 group (p < 0.05, Figure 6(c)–(e)). This evidence concerns the gene CCND1 and lung cancer.