The interpretation of these observations should account for the endogenous expression of the miRNAs of interest and their targets: DND-41 cells express both miRNAs at high levels as compared to T-ALL primary samples and all studied controls, and express both PTEN and BIM; CCRF-CEM cells express high level of hsa-miR-20b-5p, but relatively lower level of hsa-miR-363-3p, and lack PTEN expression. Here, PTEN is linked to acute lymphoblastic leukemia.