PDPN and osteosarcoma: Moreover, PDPN has been reported to be overexpressed in various types of human tumors, and it is reported that 100% of glioma [10], 100% of lymphangioma [11], 98% of germ cell tumor [12], 94% of angiosarcoma [13], 86% of malignant mesothelioma [14], 80% of squamous cell carcinoma (SCC) [15,16], 80% of osteosarcoma [17], 78% of hemangioendothelioma [18], 36% of pleomorphic carcinoma of the lung overexpressed PDPN [19].