This assertion is based on the appearance of coronavirus particles in the urine, the tubular expression pattern of ACE2 (a receptor for the virus)—which parallels the sites of injury in the kidneys of patients with SARS-CoV infection—and the correlation of the timeline of SARS-CoV viral shedding in the urine with the onset of AKI (Kidney International, Feb. This evidence concerns the gene ACE2 and severe acute respiratory syndrome.