SIRT3 and ischemic stroke: In addition, it was found that SIRT3 KO mice showed worse neurobehavioral outcome compared with WT mice, accompanied by decreased neurogenesis and angiogenesis, as shown by the reduction in number of DCX+/BrdU+ cells, NeuN+/BrdU+ cells, and CD31+/BrdU+ cells in the perifocal region during the recovery phase after ischemic stroke [103].