SIRT3 and Parkinson disease: Interestingly, while it was shown that SIRT3 null mice do not exhibit motor and non-moto deficits compared with wild-type controls, SIRT3 deficiency dramatically exacerbated the degeneration of nigrostriatal dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice [92].