The second most frequent PV, found in 12 families and involving a total of 49 subjects (10.1%), including 20 cancer patients (12 probands and 8 family members), is named BRCA2-1466delT (HGVS nomenclature: c.1238del; p.Leu413fs) [43,44,45,46]. The gene discussed is BRCA2; the disease is cancer.