BRCA1 and ovarian cancer: Among 102 BRCA1 PV carriers, 59 individuals (57.8%) had female breast cancer, 8 of which bilateral (13.5%), 19 triple-negative breast cancer (TNBC) (32.2%) and 9 diagnosed before age 35 years (15.2%), 29 patients (28.4%) had ovarian cancer, 27 of which high-grade serous (93.1%) and 2 endometrioid (6.9%), 11 subjects (10.8%) had both primary ovarian and breast cancer, 3 patients (2.9%) had male breast cancer (Figure 1a; Table 1).