BRCA1 and cancer: Another recurrent founder PV, named BRCA1-C61G (HGVS nomenclature: c.181T > G; p.Cys61Gly) and identified mainly in Eastern European populations (Polish, Czech, Slovenian, Austrian, Hungarian, Belarusian and German) [38], has also been observed in our study population (8 PV carriers, including 2 cancer patients).