BRCA1 and cancer: Furthermore, a common Ashkenazi founder PV consisting of a BRCA1 duplication named 5382insC (HGVS nomenclature: c.5266dupC; p.Gln1756Profs) [56] has been mainly observed in some families from the North-eastern coast of Sicily belonging to the city of Messina (11 individuals, including 6 cancer patients).