The 2′,5′-oligoadenylate synthase (OAS) and RNase L pathways have previously been shown to restrict flavivirus infection [83,84,85], yet in ZIKVPR-infected SH-SY5Y cells, we observed that OAS3 was downregulated (Figure S4), while OASL was notably upregulated (Figure 3b). The gene discussed is RNASEL; the disease is Flavivirus Infections.