FFAR2 and colonic neoplasm: Clostridium butyricum inhibited proliferation of colorectal cancer cells, increased cell-cycle arrest and apoptosis of colon cancer cells, and modulated T-cells [58]Clostridium butyricum increased SCFAs and G-protein coupled receptor GPR43, suppressed tumor cell proliferation, increased tumor-cell apoptosis, and suppressed the Wnt/β-catenin signaling pathway [59]