Protection against CRC was dependent on B. fragilis polysaccharide A production and toll-like receptor 2 (TLR2) signaling and associated with inhibition of C-C motif chemokine receptor5 (CCR5) in colon [13] Inhibition of cell cycle progression and inhibition of EMT and cancer cell migration and invasion in TLR2 dependent manner [57]. The gene discussed is TLR2; the disease is cancer.