TIGIT and colorectal carcinoma: FadA promoted the E-cadherin/beta-catenin-mediated proliferation of CRC cells in vitro and E-cadherin-mediated growth of CRC and expression of pro-inflammatory cytokines in vivo [18] Immune evasion mediated by inhibition of NK and T-cell anti-tumor activity upon Fap2 binding to the inhibitory receptor TIGIT [48]