TIGIT and colorectal carcinoma: F. nucleatum mediated promotion of CRC may involve FadA adhesion mediated modulation of E-cadherin/β-catenin signaling [17] and Fap2 binding to inhibitory receptor TIGIT (T cell immunoreceptor with Ig and ITIM domains) and subsequent inhibition of NK cell mediated cytotoxicity and T-cell activity [18].