MAPT and early-onset autosomal dominant Alzheimer disease: This suggests a driving role of neuroinflammation in tau spread and neurodegeneration in Alzheimer’s disease (Yoshiyama et al., 2007; Asai et al., 2015; Maphis et al., 2015), in which activated microglia facilitate tau spread (Maphis et al., 2015; Perea et al., 2018).