MAPT and Cognitive impairment: This is also in keeping with evidence that tau deposition is evident as a continuum from normal ageing through MCI to Alzheimer’s dementia (Schöll et al., 2019), and correlates with cognitive impairment (Brier et al., 2016; Cho et al., 2016b; Johnson et al., 2016; Ossenkoppele et al., 2016; Pontecorvo et al., 2017).