MAPT and early-onset autosomal dominant Alzheimer disease: We predicted: (i) a significant association between baseline measures of each neuroimaging technique and longitudinal decline in cognition; (ii) partially independent and additive effects of MRI and PET measures on cognitive decline, assessed with all modalities together in a single multivariate model; and (iii) that the molecular markers of baseline tau and neuroinflammation PET would be more informative than structural MRI on longitudinal cognitive deterioration in Alzheimer’s disease.