(2019) found that both 18F-AV-1451 PET and structural brain MRI are associated with cognition in Alzheimer’s disease (spanning preclinical, prodromal, and dementia stages), although associations of tau PET indices were stronger than those for MRI markers (Mattsson et al., 2019). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.