18F-AV-1451 bindings also correlates with Braak staging of neurofibrillary tau (Schöll et al., 2016; Schwarz et al., 2016), and post-mortem patterns of Alzheimer’s disease pathology (Sander et al., 2016; Lowe et al., 2020; Smith et al., 2019). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.