MAPT and early-onset autosomal dominant Alzheimer disease: The pathological hallmarks of Alzheimer’s disease are tau neurofibrillary tangles and amyloid-β plaques, but neuroinflammation has also emerged as a key process in Alzheimer’s disease and other neurodegenerative disorders (Pasqualetti et al., 2015; Ransohoff, 2016; Schain and Kreisl, 2017).