,25 Recent studies confirmed that miR-1 suppresses cardiac hypertrophy by inhibiting the expression of various downstream targets, including fibulin-2 (FBLN2),26 twinfilin-1 (TWF1),27 CALM1 and CALM2, MEF2A,28 MYLK3,29 and GATA4.30 Here, FBLN2 is linked to cardiac hypertrophy.