Recently, lncRNA Myheart (Mhrt), which originates the from MYH7 locus and is enriched in adult hearts, was found to protect the adult heart from pathological hypertrophy by interacting with the helicase domain of Brg1 and inhibiting the function of Brg1, a chromatin-remodeling factor that is activated by stress and triggers aberrant gene expression and cardiomyopathy.68 The gene discussed is SMARCA4; the disease is cardiomyopathy.