MAPT and Alzheimer disease: For example, the administration of SSRIs in AD in human studies (Lyketsos et al., 2003) and preclinical studies (animal models) have demonstrated a commendable influence of SSRIs on pathological markers of AD including Aβ accumulation, tau deposits, and neurogenesis (Kim et al., 2013; Qiao et al., 2016; Sheline et al., 2014; Wang et al., 2014, 2016).