PTGS1 and Hernia: Six of the genes DE in our study were mapped to QTL regions already described in the literature for umbilical hernias in pigs: ACER2, SLC2A6, PTGS1, LGALS3, KANK3 and FOS. These genes have very distinct functions, such as cell proliferation and survival (ACER2) [100], regulation of prostaglandin (PTGS1) [101] and glucose transport (SLC2A6) [102].