In the exploratory phase, 33 proteins met the final filtering criteria of which nine proteins (EC-SOD, IGFBP-5, IGFBP-7, LCN15, MFAP4, NGAL, PAI-1, SEMA A (V) and U-II) were associated with spontaneous PTD and gestational duration adjusting for gestational age at sampling. The gene discussed is SERPINE1; the disease is Bjornstad syndrome.